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Orthogonal Regioselective Synthesis of N ‐Alkyl‐3‐substituted Tetrahydroindazolones
Author(s) -
Kim Jonghoon,
Song Heebum,
Park Seung Bum
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000516
Subject(s) - regioselectivity , chemistry , alkyl , structural isomer , intermolecular force , generality , condensation , stereochemistry , combinatorial chemistry , organic chemistry , molecule , catalysis , physics , thermodynamics , psychology , psychotherapist
A divergent strategy for the regioselective and orthogonal synthesis of complementary regioisomers of N ‐alkyl‐3‐substituted‐tetrahydroindazolones 3 and 4 was achieved from Boc‐protected alkylhydrazines 1 . The robustness and substrate generality of this method were validated by synthesizing 3 and 4 through the intra‐ and intermolecular condensation of 1 with various 2‐acylcyclohexane‐1,3‐diones 2 and aldehydes, respectively.
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