Premium
Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol
Author(s) -
Wang Xin,
Liu Lingyan,
Chang Weixing,
Li Jing
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000515
Subject(s) - sonogashira coupling , chemistry , palladium , aryl , indene , catalysis , combinatorial chemistry , alcohol , domino , cascade reaction , suzuki reaction , cascade , organic chemistry , alkyl , chromatography
A novel cascade combination reaction catalyzed by a single palladium source for the synthesis of various indene derivatives is reported. The approach involved sequential Sonogashira/carbopalladative cyclization/Suzuki coupling reactions by using three readily available components, such as homopropargyl alcohol, aryl iodides or aryl bromides, and arylboronic acids. The overall domino reaction yields were up to 70 %.