Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol | Zendy

Wang Xin | Zendy; Liu Lingyan | Zendy; Chang Weixing | Zendy; Li Jing | Zendy

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Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol

Author(s) -

Wang Xin,

Liu Lingyan,

Chang Weixing,

Li Jing

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000515

Subject(s) - sonogashira coupling , chemistry , palladium , aryl , indene , catalysis , combinatorial chemistry , alcohol , domino , cascade reaction , suzuki reaction , cascade , organic chemistry , alkyl , chromatography

A novel cascade combination reaction catalyzed by a single palladium source for the synthesis of various indene derivatives is reported. The approach involved sequential Sonogashira/carbopalladative cyclization/Suzuki coupling reactions by using three readily available components, such as homopropargyl alcohol, aryl iodides or aryl bromides, and arylboronic acids. The overall domino reaction yields were up to 70 %.

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