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Diastereoselective Synthesis of 1,2‐Disubstituted 2,3,4,5‐Tetrahydro‐1 H ‐3‐benzazepines by Means of the Stevens Rearrangement
Author(s) -
Valpuesta María,
Ariza Manuela,
Díaz Amelia,
Suau Rafael
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000512
Subject(s) - benzazepines , chemistry , acetonitrile , stereochemistry , organic chemistry
1,2‐Disubstituted 2,3,4,5‐tetrahydro‐1 H ‐3‐benzazepines were conveniently obtained by making use of the regio‐ and diastereoselective Stevens rearrangement of the corresponding isoquinolinium salts with 1,8‐diazabicyclo[5.4.0]undec‐7‐ene in acetonitrile. This procedure has provided a good number of novel analogue compounds of SCH 23390.