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Practical Synthetic Approach to Chiral Sulfonimides (CSIs) – Chiral Brønsted Acids for Organocatalysis
Author(s) -
He Hao,
Chen LingYan,
Wong WaiYeung,
Chan WingHong,
Lee Albert W. M.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000477
Subject(s) - chemistry , organocatalysis , sulfonyl , brønsted–lowry acid–base theory , enantioselective synthesis , aryl , chirality (physics) , organic chemistry , optically active , combinatorial chemistry , catalysis , chiral symmetry , alkyl , physics , quantum mechanics , quark , nambu–jona lasinio model
Abstract A general approach to the synthesis of optically pure 3,3′‐diaryl chiral sulfonimides (CSIs) from racemic BINOL has been developed. ortho ‐Lithiation is directed by the sulfonyl groups, and the resulting dihalides serve as the common precursors for the aryl‐substituted CSIs.