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Recent Progress in the Chemically Catalyzed Enantioselective Synthesis of Cyanohydrins
Author(s) -
Wang Wentao,
Liu Xiaohua,
Lin Lili,
Feng Xiaoming
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000462
Subject(s) - enantioselective synthesis , chemistry , cyanation , catalysis , organic chemistry , combinatorial chemistry , substrate (aquarium) , organic synthesis , oceanography , geology
The catalytic enantioselective cyanation of aldehydes and ketones has received growing attention because the resulting enantiomerically pure cyanohydrins are versatile building blocks for many biologically active compounds. To date, both metal‐based and organic catalysts have been successfully developed to promote these reactions enantioselectively. Great advances have been made in the catalytic enantioselective addition of various cyanide sources to carbonyl compounds. In this microreview, recent progress, including substrate scope and limitations, and probable reaction mechanisms are discussed. In addition, the application of this methodology to the synthesis of natural products is also presented briefly where appropriate.