Premium
Novel Approach for the Synthesis of Five‐Membered‐Ring‐Fused Pyrazinones
Author(s) -
Gembus Vincent,
Janvier Solenn,
Lecouvé JeanPierre,
Gloanec Philippe,
Marsais Francis,
Levacher Vincent
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000435
Subject(s) - chemistry , moiety , intramolecular force , alkylation , ring (chemistry) , glycine , yield (engineering) , combinatorial chemistry , stereochemistry , organic chemistry , amino acid , catalysis , biochemistry , materials science , metallurgy
We describe a new route to access important pharmaceutical intermediates for the synthesis of constrained fused pyrazinones. These compounds are prepared in five to seven steps with a good overall yield from glycine methyl ester and commercial propanediol derivatives involving an intramolecular alkylation of a glycine moiety as key step.