Novel Approach for the Synthesis of Five‐Membered‐Ring‐Fused Pyrazinones | Zendy

Gembus Vincent | Zendy; Janvier Solenn | Zendy; Lecouvé JeanPierre | Zendy; Gloanec Philippe | Zendy; Marsais Francis | Zendy; Levacher Vincent | Zendy

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Novel Approach for the Synthesis of Five‐Membered‐Ring‐Fused Pyrazinones

Author(s) -

Gembus Vincent,

Janvier Solenn,

Lecouvé JeanPierre,

Gloanec Philippe,

Marsais Francis,

Levacher Vincent

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000435

Subject(s) - chemistry , moiety , intramolecular force , alkylation , ring (chemistry) , glycine , yield (engineering) , combinatorial chemistry , stereochemistry , organic chemistry , amino acid , catalysis , biochemistry , materials science , metallurgy

We describe a new route to access important pharmaceutical intermediates for the synthesis of constrained fused pyrazinones. These compounds are prepared in five to seven steps with a good overall yield from glycine methyl ester and commercial propanediol derivatives involving an intramolecular alkylation of a glycine moiety as key step.

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