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Iron‐Catalyzed Cross‐Coupling between 1‐Bromoalkynes and Grignard‐Derived Organocuprate Reagents
Author(s) -
Castagnolo Daniele,
Botta Maurizio
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000393
Subject(s) - chemistry , reagent , grignard reagent , stereoselectivity , catalysis , grignard reaction , combinatorial chemistry , coupling (piping) , coupling reaction , organic chemistry , metallurgy , materials science
An efficient iron‐catalyzed cross‐coupling reaction between alkynyl bromides and Grignard‐derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1‐bromoalkynes and Grignard reagents. The methodology was successfully used for the two‐step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.