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Amination of Aryl Iodides Using a Fluorous‐Tagged Ammonia Equivalent
Author(s) -
Nielsen Simon Dalsgaard,
Smith Garrick,
Begtrup Mikael,
Kristensen Jesper Langgaard
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000367
Subject(s) - chemistry , amination , aryl , yield (engineering) , ammonia , extraction (chemistry) , organic chemistry , reductive amination , solid phase extraction , combinatorial chemistry , catalysis , alkyl , materials science , metallurgy
A fluorous‐tagged ammonia equivalent for the Cu‐catalyzed amination of aryl iodides is described in which N ‐Boc‐protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous Solid‐Phase Extraction (F‐SPE) greatly simplifying and speeding up the isolation of the desired products.