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Aza‐Michael Addition Reactions of Hydrazones with Activated Alkynes Catalyzed by Nitrogen‐Containing Organic Bases
Author(s) -
Yuan ZhiLiang,
Wei Yin,
Shi Min
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000365
Subject(s) - dabco , chemistry , michael reaction , adduct , octane , catalysis , hydrazone , organic chemistry , nitrogen , medicinal chemistry
Several highly efficient DABCO (1,4‐diazabicyclo[2.2.2]octane)‐catalyzed Michael‐type reactions of hydrazones with activated alkynes are described in this paper. This aza‐Michael addition reaction can be applied to different types of hydrazones, such as hydrazones 1 and hydroxy‐bearing hydrazones 5 . The corresponding adducts are achieved in high yields under mild reaction conditions. DABCO‐promoted aza‐Michael addition reactions were successfully applied to a serious of hydrazones with activated alkynes to afford the corresponding adducts in moderate to good yields.