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Metabolites from the Mangrove Endophytic Fungus Phomopsis sp. (#zsu‐H76)
Author(s) -
Yang Jianxiang,
Xu Fang,
Huang Caihuan,
Li Jing,
She Zhigang,
Pei Zhong,
Lin Yongcheng
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000329
Subject(s) - mangrove , chemistry , phomopsis , fungus , stereochemistry , plant use of endophytic fungi in defense , endophyte , botany , biology , ecology
Three unique metabolites, namely, phomopsis‐H76 A ( 1 ), B ( 2 ), and C ( 3 ), were isolated from the mangrove endophytic fungus Phomopsis sp. (#zsu‐H76). Structures were determined by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. Compound 1 – 3 are all dimers. Compounds 2 and 3 possesses a pyrano[4,3‐ b ]pyran‐5(2 H )‐one ring system that is unprecedented in nature. Primary bioassays showed that 1 accelerated the growth of subintestinal vessel plexus (SIV) branch markedly, whereas 3 showed inhibition of SIV. Compounds 1 – 3 showed no activity in antibacterial and cytotoxic tests.