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Synthetic Strategies Directed Towards the Cortistatin Family of Natural Products
Author(s) -
Hardin Narayan Alison R.,
Simmons Eric M.,
Sarpong Richmond
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000247
Subject(s) - chemistry , natural (archaeology) , combinatorial chemistry , computational biology , biology , archaeology , history
Abstract Since their isolation by Kobayashi and co‐workers, the cortistatins have captured the attention both of the synthetic chemistry community and of researchers interested in exploiting the potent anti‐angiogenic activity of these natural products. The unique rearranged steroidal cortistatin core has become the target of numerous synthetic efforts, which are detailed herein.