Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions | Zendy

Ramachary Dhevalapally B. | Zendy; Mondal Rumpa | Zendy; Venkaiah Chintalapudi | Zendy

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Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions

Author(s) -

Ramachary Dhevalapally B.,

Mondal Rumpa,

Venkaiah Chintalapudi

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000220

Subject(s) - chemistry , cascade , catalysis , combinatorial chemistry , glucocorticoid receptor , organic synthesis , receptor , organic chemistry , stereochemistry , biochemistry , chromatography

A general process for the synthesis of substituted indenes and 1,2,3‐triazoles was achieved for the first time through a multicatalysis cascade reaction of 2‐ethynylbenzaldehydes, CH acids, organic hydrides, and azides in the presence of a catalytic amount of L ‐proline/CuI/DIPEA. In this communication, we discovered the utilization of a single copper catalyst for two different reactions and shown synthetic application to the high‐yielding synthesis of glucocorticoid receptor modulators.

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