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Ni II –(σ‐Aryl) Complex Catalyzed Suzuki Reaction of Aryl Tosylates with Arylboronic Acids
Author(s) -
Fan XinHeng,
Yang LianMing
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000147
Subject(s) - chemistry , aryl , catalysis , yield (engineering) , toluene , combinatorial chemistry , ligand (biochemistry) , nickel , base (topology) , organic chemistry , suzuki reaction , palladium , alkyl , mathematical analysis , biochemistry , materials science , receptor , mathematics , metallurgy
A practical, efficient protocol was developed for the Suzuki reaction of aryl tosylates with arylboronic acids. The process was promoted by a nickel‐based catalyst system consisting of the easily available Ni II –(σ‐aryl) complex and the simple ligand PPh 3 in toluene in the presence of the base K 2 CO 3 . The convenient operation, high yield, generality, and low cost make this method viable for most common laboratories and applicable in large‐scale preparations.