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Palladium‐Catalyzed Synthesis of 4‐Arylcoumarins Using Triarylbismuth Compounds as Atom‐Efficient Multicoupling Organometallic Nucleophiles
Author(s) -
Rao Maddali L. N.,
Venkatesh Varadhachari,
Jadhav Deepak N.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000134
Subject(s) - chemistry , nucleophile , palladium , trifluoromethanesulfonate , catalysis , reagent , bromide , group 2 organometallic chemistry , combinatorial chemistry , organometallic chemistry , organic chemistry , medicinal chemistry , molecule
Triarylbismuth compounds have been cross‐coupled as atom‐efficient multicoupling organometallic nucleophiles with 4‐bromo‐ and 4‐(trifluoromethylsulfonyloxy)coumarins under palladium catalysis conditions. These reactions afforded an array of 4‐arylcoumarins in high yields. The general palladium protocol has been demonstrated to be efficient for the coupling of both bromide and triflate derivatives of coumarins with triarylbismuth reagents.