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Enantioselective Arylations Catalyzed by Carbohydrate‐Based Chiral Amino Alcohols
Author(s) -
Wouters Ana Dionéia,
Trossini Gustavo H. G.,
Stefani Hélio A.,
Lüdtke Diogo S.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000113
Subject(s) - chemistry , enantioselective synthesis , xylose , enantiomer , aryl , carbohydrate , catalysis , organic chemistry , amino acid , alcohol , ligand (biochemistry) , sugar , combinatorial chemistry , biochemistry , fermentation , alkyl , receptor
The application of carbohydrate‐derived amino alcohols in the asymmetric arylation of aldehydes by using arylboronic acids as the source of transferable aryl groups is described. The best ligand is derived from the readily available sugar D ‐xylose and it mediates the addition of a range of arylboronic acids to various aromatic aldehydes in excellent yields and high enantiomeric excesses.

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