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Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2‐(Purin‐9‐yl)ethoxyphenylphosphonic Acids
Author(s) -
Hocková Dana,
Dračínský Martin,
Holý Antonín
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000061
Subject(s) - chemistry , moiety , nucleoside , stereochemistry , titration , combinatorial chemistry , organic chemistry
Abstract A series of novel acyclic nucleoside phosphonates with a built‐in arylphosphonate moiety has been prepared by a microwave‐assisted cross‐coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The p K a values of the target ortho ‐, meta ‐ and para ‐substituted arylphosphonates were determined by 31 P NMR titration studies.