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A Simple and Efficient Catalytic System for Coupling Aryl Halides with Aqueous Ammonia in Water
Author(s) -
Wu Zhiqing,
Jiang Zhaoqiong,
Wu Di,
Xiang Haifeng,
Zhou Xiangge
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000060
Subject(s) - chemistry , aryl , halide , benzimidazole , catalysis , ammonia , aqueous solution , aqueous medium , coupling (piping) , coupling reaction , organic chemistry , combinatorial chemistry , alkyl , mechanical engineering , engineering
The cross‐coupling reaction between aryl halides andaqueous ammonia was efficiently catalyzed by the sulfonato–Cu(salen) complex in water with high yields. A variety of substituted aryl bromides and aryl iodides were found to be applicable to the environmentally benign system. Substituted 1 H ‐benzimidazole could also be easily prepared by coupling aqueous ammonia with 2‐iodoacetanilide in one pot with this catalytic system.