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Microwave‐Promoted, One‐Pot, Solvent‐Free Synthesis of 4‐Arylcoumarins from 2‐Hydroxybenzophenones
Author(s) -
CrecenteCampo José,
Pilar VázquezTato M.,
Seijas Julio A.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000051
Subject(s) - chemistry , knoevenagel condensation , intramolecular force , decarboxylation , microwave irradiation , organic chemistry , malonate , green chemistry , solvent , alkyl , combinatorial chemistry , catalysis , reaction mechanism
Abstract 4‐Arylcoumarins are synthesized in very good yields through solvent‐free microwave irradiation of 2‐hydroxybenzophenones and alkyl malonate in the presence of DBU. The one‐pot synthesis is carried out with Knoevenagel condensation, intramolecular lactonization, and decarboxylation reactions. The method can be applied to a broad scope of neoflavonoids.