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Enamine–Metal Lewis Acid Bifunctional Catalysis: Application to Direct Asymmetric Aldol Reaction of Ketones (Eur. J. Org. Chem. 27/2009)
Author(s) -
Xu Zhenghu,
Daka Philias,
Budik Ilya,
Wang Hong,
Bai FuQuan,
Zhang HongXing
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200990075
Subject(s) - bifunctional , chemistry , enamine , aldol reaction , lewis acids and bases , lewis acid catalysis , catalysis , bifunctional catalyst , organocatalysis , enantioselective synthesis , organic chemistry , combinatorial chemistry
The cover picture shows aldol reactions catalyzed by an enamine–metal Lewis acid bifunctional catalyst. The proposed transition state is also shown at the top. This bifunctional catalyst was developed by using a tridentate ligand to bring the Lewis acid and Lewis base in close proximity without quenching each other. The catalyst was found to catalyze aldol reactions in high activity and stereoselectivity. Details are discussed in the Short Communication by H. Wong et al. on p. 4581 ff. The authors acknowledge Bo Wang for helping with the cover page design and Mike Novak for useful discussions.