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Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper‐Catalysed Reaction of Fluoro Alcohols (Eur. J. Org. Chem. 21/2009)
Author(s) -
Vuluga Daniela,
Legros Julien,
Crousse Benoit,
BonnetDelpon Danièle
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200990057
Subject(s) - chemistry , aryl , moiety , lipophilicity , iodide , halide , medicinal chemistry , copper , substrate (aquarium) , combinatorial chemistry , organic chemistry , polymer chemistry , alkyl , oceanography , geology
The cover picture shows the reaction between fluoro alcohols and aryl halides in the presence of copper iodide to afford fluoro ethers. The incorporation of the trifluoroethoxy moiety generally brings lipophilicity and metabolic stability to the substrate, and this group is found in numerous pharmaceuticals such as Flecainide. Details are discussed in the article by J. Legros, B. Crousse et al. on p. 3513 ff. The Région Ile‐de‐France is kindly acknowledged for support.