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Click Multivalent Homogeneous Neoglycoconjugates – Synthesis and Evaluation of Their Binding Affinities (Eur. J. Org. Chem. 15/2009)
Author(s) -
PerezBalderas Francisco,
MoralesSanfrutos Julia,
HernandezMateo Fernando,
IsacGarcía Joaquín,
SantoyoGonzalez Francisco
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200990038
Subject(s) - chemistry , affinities , binding affinities , homogeneous , click chemistry , combinatorial chemistry , stereochemistry , biochemistry , receptor , physics , thermodynamics
The cover picture shows two copper(I) click‐based strategies for accessing multivalent neoglyconjugates by the coupling of complementary functionalized scaffolds and sugar derivatives. The methodology allows the easy preparation of structurally diverse homogeneous neoglycoconjugates from which the influence of the structural parameters in the binding affinities toward Concanavalin A could be evaluated. Details are discussed in the article by F. Santoyo‐Gonzalez et al. on page 2441ff.