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Dizinc Phosphohydrolase Model Built on a m ‐Terphenyl Scaffold and Its Use in Indicator Displacement Assays for Pyrophosphate Under Physiological Conditions (Eur. J. Org. Chem. 3/2009)
Author(s) -
Coggins Michael K.,
Parker Austa M.,
Mangalum Anshuman,
Galdamez Gabriela A.,
Smith Rhett C.
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200990000
Subject(s) - chemistry , pyrophosphate , terphenyl , displacement (psychology) , scaffold , stereochemistry , combinatorial chemistry , enzyme , biochemistry , organic chemistry , database , psychology , computer science , psychotherapist
The cover picture shows a dizinc phosphohydrolase model built on a m ‐terphenyl scaffold that binds pyrophosphate with concomitant displacement of complexometric indicators; this leads to dramatic color changes that can be detected visually and quantified spectroscopically. Details are discussed in the article by R. C. Smith et al. on p. 343 ff.