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Noyori's Ts‐DPEN Ligand: Simple yet Effective Catalyst for the Highly Enantioselective Michael Addition of Acetone to Nitroalkenes
Author(s) -
Peng Lin,
Xu XiaoYing,
Wang LiangLiang,
Huang Jun,
Bai JianFei,
Huang QingChun,
Wang LiXin
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901509
Subject(s) - enantioselective synthesis , chemistry , bifunctional , acetone , michael reaction , ligand (biochemistry) , terephthalic acid , catalysis , organic chemistry , amine gas treating , organocatalysis , combinatorial chemistry , polyester , biochemistry , receptor
Abstract Highly enantioselective Michael addition of acetone to a variety of nitroalkenes promoted by simple chiral primary amine bifunctional catalysts (e.g., Noyori's Ts‐DPEN ligand) together with terephthalic acid in excellent yields (84–99 %) and enantioselectivities (93–98 % ee ) is reported.