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Efficient Synthesis of Biaryls through the Kumada Reaction Catalyzed by Carbene Adducts of Cyclopalladated Ferrocenylimine
Author(s) -
Ren Gerui,
Cui Xiuling,
Wu Yangjie
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901495
Subject(s) - chemistry , carbene , aryl , steric effects , catalysis , reagent , adduct , coupling reaction , halide , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
A series of carbene adducts of cyclopalladated ferrocenylimine were prepared and evaluated in the cross‐coupling reaction of aryl halides with Grignard reagents (the Kumada reaction). Complex d exhibited high catalytic activity for the coupling of aryl chlorides with sterically hindered Grignard reagents and the reaction tolerated various functional groups. A wide range of biaryls were efficiently obtained in good to excellent yields in the presence of 0.5 mol‐% catalyst under mild reaction conditions.