Efficient Synthesis of Biaryls through the Kumada Reaction Catalyzed by Carbene Adducts of Cyclopalladated Ferrocenylimine | Zendy

Ren Gerui | Zendy; Cui Xiuling | Zendy; Wu Yangjie | Zendy

Premium

Efficient Synthesis of Biaryls through the Kumada Reaction Catalyzed by Carbene Adducts of Cyclopalladated Ferrocenylimine

Author(s) -

Ren Gerui,

Cui Xiuling,

Wu Yangjie

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200901495

Subject(s) - chemistry , carbene , aryl , steric effects , catalysis , reagent , adduct , coupling reaction , halide , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl

A series of carbene adducts of cyclopalladated ferrocenylimine were prepared and evaluated in the cross‐coupling reaction of aryl halides with Grignard reagents (the Kumada reaction). Complex d exhibited high catalytic activity for the coupling of aryl chlorides with sterically hindered Grignard reagents and the reaction tolerated various functional groups. A wide range of biaryls were efficiently obtained in good to excellent yields in the presence of 0.5 mol‐% catalyst under mild reaction conditions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research