Premium
Enantioselective Synthesis of Daurichromenic Acid and Confluentin
Author(s) -
Liu Kegang,
Woggon WolfD.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901403
Subject(s) - enantioselective synthesis , chemistry , aldol reaction , total synthesis , stereochemistry , organic chemistry , organocatalysis , michael reaction , sequence (biology) , combinatorial chemistry , catalysis , biochemistry
The first asymmetric synthesis of daurichromenic acid and confluentin is described. The key step of the sequence leading to both natural products is a highly enantioselectivedomino aldol/oxa Michael reaction (97 % ee ) of farnesal and 2‐methoxy‐4‐methylsalicylaldehyde.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom