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Facile Assembly of Fused Isoquinolines by Gold(I)‐Catalyzed Coupling–Cyclization Reactions between o ‐Alkynylbenzaldehydes and Aromatic Amines Containing Tethered Nucleophiles
Author(s) -
Patil Nitin T.,
Mutyala Anil Kumar,
Lakshmi Pediredla G. V. V.,
Raju Penmatcha V. K.,
Sridhar Balasubramanian
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901364
Subject(s) - isoquinoline , chemistry , nucleophile , combinatorial chemistry , catalysis , coupling reaction , reaction conditions , coupling (piping) , organic chemistry , mechanical engineering , engineering
A gold(I)‐catalyzed, operationally simple coupling–cyclization technique was developed for the synthesis of isoquinoline‐fused polycyclic compounds. The reaction makes use of two coupling partners such as o ‐alkynylbenzaldehydes and aromatic amines having tethered nucleophiles. The reaction is easy to perform, broad in scope, and allows the generation of a number of biologically important heterocyclic motifs from readily accessible starting materials. A mechanism for the reaction is discussed.
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