Premium
General Multicomponent Strategy for the Synthesis of 2‐Amino‐1,4‐diazaheterocycles: Scope, Limitations, and Utility
Author(s) -
Kysil Volodymyr,
Khvat Alexander,
Tsirulnikov Sergey,
Tkachenko Sergey,
Williams Caroline,
Churakova Marina,
Ivachtchenko Alexandre
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901360
Subject(s) - chemistry , scope (computer science) , combinatorial chemistry , primary (astronomy) , lewis acids and bases , amino acid , organic chemistry , catalysis , biochemistry , computer science , programming language , physics , astronomy
Multicomponent reactions of primary 1,2‐ and 1,3‐diamines with carbonyl compounds and isocyanides resulting in the formation of diverse 2‐amino‐1,4‐diazaheterocycles are described. Lewis acids (LAs) promote the reactions effectively, and chlorotrimethylsilane (TMSCl) has been found to be a promoter of choice. The scope and limitations of the reactions with regard to each of the components are evaluated and discussed. Post‐IMCR modifications of the synthesized heterocycles have been elaborated.