Premium
Uncatalyzed Three‐Component Synthesis of α‐Hydrazido Phosphonates
Author(s) -
Herrera Raquel P.,
RocaLópez David,
NavarroMoros Gloria
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901337
Subject(s) - chemistry , enantioselective synthesis , nucleophile , component (thermodynamics) , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , physics , thermodynamics
Various α‐hydrazido phosphonates have been easily prepared on the basis of the nucleophilic addition of diphenyl phosphite to reactive, preformed N ‐acylhydrazones and a three‐component (aldehydes, N ‐benzoylhydrazide and diphenyl phosphite) coupling reaction through a non‐catalyzed process. An unprecedented and promising enantioselective example of this reaction is also reported.