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Rapid and General Protocol towards Catalyst‐Free Friedel–Crafts C ‐Alkylation of Indoles in Water Assisted by Microwave Irradiation
Author(s) -
De Rosa Margherita,
Soriente Annunziata
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901333
Subject(s) - chemistry , friedel–crafts reaction , microwave irradiation , alkylation , catalysis , indole test , microwave , organic chemistry , physics , quantum mechanics
An efficient and simplified protocol for uncatalyzed Friedel–Crafts alkylation of indoles using microwave irradiation in water is described. A series of functionalized indole derivatives has been synthesized in very short times with moderate to good yields. The combination of microwave irradiation and superheated water offers significant advantages over conventional methods, such as higher selectivities, simplicity, shorter reaction times, and no need for a catalyst.