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Chiral Isocyanoazides: Efficient Bifunctional Reagents for Bioconjugation
Author(s) -
Nenajdenko Valentine G.,
Gulevich Anton V.,
Sokolova Nadezhda V.,
Mironov Andrey V.,
Balenkova Elizabeth S.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901326
Subject(s) - bioconjugation , chemistry , bifunctional , isocyanide , ugi reaction , combinatorial chemistry , click chemistry , azide , reagent , peptide , amino acid , organic chemistry , catalysis , biochemistry
Chiral scaffolds combining isocyanide and azide groups can be effectively synthesized to permit the efficient construction of both amino (hydroxy) acids and triazole derivatives, which enables the preparation of hybrid peptide molecules by Ugi/click or click/Ugi strategies.