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Recent Developments in the Synthesis of Pyrrolidine‐Containing Iminosugars
Author(s) -
Stocker Bridget L.,
Dangerfield Emma M.,
WinMason Anna L.,
Haslett Gregory W.,
Timmer Mattie S. M.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901320
Subject(s) - pyrrolidine , chemistry , iminosugar , aldol reaction , combinatorial chemistry , ring closing metathesis , metathesis , organic chemistry , catalysis , enzyme , polymer , polymerization
As noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment of a number of diseases such as cancer, diabetes, and lysosomal storage disorders. Accordingly, much effort has been expended over the past decades in developing novel and efficient methodologies for the synthesis of iminosugars. This microreview highlights recent (post 2005) developments in the synthesis of pyrrolidine‐containing iminosugars and includes discussions of methodologies such as ring‐closing metathesis, aldol and pericyclic reactions, and protecting‐group free strategies.