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Quadrane Sesquiterpenes: Natural Sources, Biology, and Syntheses
Author(s) -
Presset Marc,
Coquerel Yoann,
Rodriguez Jean
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901302
Subject(s) - chemistry , isolation (microbiology) , natural compound , natural (archaeology) , ring (chemistry) , combinatorial chemistry , organic chemistry , biochemical engineering , biology , bioinformatics , engineering , paleontology
Quadranes, discovered with the isolation of (–)‐quadrone in 1978, are biologically active naturally occurring sesquiterpenes featuring a distinctive set of bi‐ to tetracyclic ring systems. The available data for this family of natural products, including isolation data, biosynthetic considerations, a comprehensive compilation of the reported biological activities, and an exhaustive survey of the synthetic work in this area so far, are critically analyzed.