Efficient Synthesis of Glycoporphyrins by Microwave‐Mediated “Click” Reactions

The Cu I ‐catalysed Huisgen cycloaddition “click” reaction has been applied to the synthesis of a range of triazole‐linked glycoporphyrins. The “click” reaction under microwave‐heating conditions has been shown to provide a general and robust methodology for the synthesis of mono‐, di‐, tri‐ and tetra‐modified glycoporphyrins. A sequential “double‐click” process was employed to access a new class of bis‐modified 5,10‐diglycoporphyrins displaying heterogeneous carbohydrates.