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Efficient Synthesis of Glycoporphyrins by Microwave‐Mediated “Click” Reactions
Author(s) -
Locos Oliver B.,
Heindl Claudia C.,
Corral Ariadna,
Senge Mathias O.,
Scanlan Eoin M.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901292
Subject(s) - click chemistry , cycloaddition , chemistry , triazole , combinatorial chemistry , organic chemistry , catalysis
The Cu I ‐catalysed Huisgen cycloaddition “click” reaction has been applied to the synthesis of a range of triazole‐linked glycoporphyrins. The “click” reaction under microwave‐heating conditions has been shown to provide a general and robust methodology for the synthesis of mono‐, di‐, tri‐ and tetra‐modified glycoporphyrins. A sequential “double‐click” process was employed to access a new class of bis‐modified 5,10‐diglycoporphyrins displaying heterogeneous carbohydrates.