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Regioselective Arylations of α‐Amido Sulfones with Electron‐Rich Arenes through Friedel–Crafts Alkylations Catalyzed by Ferric Chloride Hexahydrate: Synthesis of Unsymmetrical and Bis‐Symmetrical Triarylmethanes
Author(s) -
Thirupathi Ponnaboina,
Kim Sung Soo
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901186
Subject(s) - chemistry , regioselectivity , friedel–crafts reaction , ferric , catalysis , chloride , medicinal chemistry , organic chemistry
Ferric chloride hexahydrate is a highly efficient catalyst for the regioselective arylation of α‐amido sulfones. The products undergo further Friedel–Crafts alkylations with heteroaromatic or electron‐rich arenes to afford unsymmetrical or bis‐symmetrical triarylmethanes.
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