Premium
Efficient Synthesis of New C ‐Functionalized Macrocyclic Polyamines
Author(s) -
Rousselin Yoann,
Sok Nicolas,
Boschetti Frédéric,
Guilard Roger,
Denat Franck
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901183
Subject(s) - synthon , chemistry , bifunctional , regioselectivity , combinatorial chemistry , chemical synthesis , functional group , chelation , organic chemistry , stereochemistry , catalysis , biochemistry , polymer , in vitro
A powerful synthetic route for the preparation of new polyazamacrocycles, valuable precursors of bifunctional chelating agents with applications in nuclear medicine, is reported. The desired functional group was introduced onto the macrocycle backbone during the cyclization step, thus avoiding the tedious preparation of a C ‐functionalized synthon. The regioselective reaction of macrocycles bearing an aminomethyl pendant arm with aldehydes is also described.