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Remarkable Reaction Rate and Excellent Enantioselective Direct α‐Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinylcamphor‐Derived Organocatalysts
Author(s) -
Liu PangMin,
Chang Chihliang,
Reddy Raju Jannapu,
Ting YingFang,
Kuan HsuanHao,
Chen Kwunmin
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901151
Subject(s) - chemistry , enantioselective synthesis , amination , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , reaction conditions
Remarkable reaction rate and excellent enantioselective direct α‐amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organocatalyst 2a (5 mol‐%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99 % ee ) at 0 °C in CH 2 Cl 2 .