Remarkable Reaction Rate and Excellent Enantioselective Direct α‐Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinylcamphor‐Derived Organocatalysts | Zendy

Liu PangMin | Zendy; Chang Chihliang | Zendy; Reddy Raju Jannapu | Zendy; Ting YingFang | Zendy; Kuan HsuanHao | Zendy; Chen Kwunmin | Zendy

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Remarkable Reaction Rate and Excellent Enantioselective Direct α‐Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinylcamphor‐Derived Organocatalysts

Author(s) -

Liu PangMin,

Chang Chihliang,

Reddy Raju Jannapu,

Ting YingFang,

Kuan HsuanHao,

Chen Kwunmin

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200901151

Subject(s) - chemistry , enantioselective synthesis , amination , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , reaction conditions

Remarkable reaction rate and excellent enantioselective direct α‐amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organocatalyst 2a (5 mol‐%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99 % ee ) at 0 °C in CH 2 Cl 2 .

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