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Kinetic Resolution of Racemic Secondary Alcohols Mediated by N ‐Methylimidazole in the Presence of Optically Active Acyl Chlorides
Author(s) -
Leclercq Loïc,
Suisse Isabelle,
AgbossouNiedercorn Francine
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901075
Subject(s) - kinetic resolution , chemistry , acylation , optically active , catalysis , organic chemistry , resolution (logic) , kinetic energy , tertiary alcohols , enantioselective synthesis , physics , quantum mechanics , artificial intelligence , computer science
N ‐Methylimidazole was used to promote the acylation of secondary racemic alcohols and to carry out their kinetic resolution through intermediate chiral acyl imidazolium chlorides. The kinetic resolution could be turned into a catalytic process in the presence of a catalytic amount of N ‐methylimidazole.