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Solid‐Phase Reactive Chromatography (SPRC): A New Methodology for Wittig and Horner–Emmons Reactions on a Column under Microwave Irradiation
Author(s) -
Dakdouki Saada C.,
Villemin Didier,
Bar Nathalie
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200901032
Subject(s) - chemistry , wittig reaction , chromatography , microwave irradiation , column chromatography , aryl , microwave , organic chemistry , catalysis , alkyl , physics , quantum mechanics
A new methodology named solid‐phase reactive chromatography (SPRC), which combines reaction, separation, and purification into a single unit for the preparation of small samples, is described. This method was illustrated in the synthesis of some natural bioactive compounds, namely, methoxylated analogues of resveratrol, alkylresorcinols, and 5‐aryl‐2,4‐pentadienoates, over a column of alumina‐KF under microwave irradiation by using the Wittig and Horner–Emmons reactions. This approach permitted the preparation of the target olefins with high purity and good to excellent yields in short reaction times.