Synthesis of  N ‐Substituted‐2‐Aminobenzothiazoles by Ligand‐Free Copper(I)‐Catalyzed Cross‐Coupling Reaction of 2‐Haloanilines with Isothiocyanates | Zendy

Shen Guodong | Zendy; Lv Xin | Zendy; Bao Weiliang | Zendy

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Synthesis of N ‐Substituted‐2‐Aminobenzothiazoles by Ligand‐Free Copper(I)‐Catalyzed Cross‐Coupling Reaction of 2‐Haloanilines with Isothiocyanates

Author(s) -

Shen Guodong,

Lv Xin,

Bao Weiliang

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900953

Subject(s) - chemistry , ligand (biochemistry) , copper , catalysis , combinatorial chemistry , cascade , coupling (piping) , coupling reaction , medicinal chemistry , stereochemistry , organic chemistry , receptor , biochemistry , chromatography , mechanical engineering , engineering

A novel and efficient formation of N ‐substituted‐2‐aminobenzothiazoles by a ligand‐free copper(I)‐catalyzed one‐pot cascade process was developed. A variety of isothiocyanates coupled with 2‐iodoanilines to give N ‐substituted‐2‐aminobenzothiazoles in moderate to excellent yields under mild conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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