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Synthesis of N ‐Substituted‐2‐Aminobenzothiazoles by Ligand‐Free Copper(I)‐Catalyzed Cross‐Coupling Reaction of 2‐Haloanilines with Isothiocyanates
Author(s) -
Shen Guodong,
Lv Xin,
Bao Weiliang
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900953
Subject(s) - chemistry , ligand (biochemistry) , copper , catalysis , combinatorial chemistry , cascade , coupling (piping) , coupling reaction , medicinal chemistry , stereochemistry , organic chemistry , receptor , biochemistry , chromatography , mechanical engineering , engineering
Abstract A novel and efficient formation of N ‐substituted‐2‐aminobenzothiazoles by a ligand‐free copper(I)‐catalyzed one‐pot cascade process was developed. A variety of isothiocyanates coupled with 2‐iodoanilines to give N ‐substituted‐2‐aminobenzothiazoles in moderate to excellent yields under mild conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)