A Cascade Approach to Captodative Trifluoromethylated Enamines or Vinylogous Guanidinium Salts: Aromatic Substituents as Switches of Reaction Direction | Zendy

Rulev Alexander Yu. | Zendy; Muzalevskiy Vasiliy M. | Zendy; Kondrashov Evgeniy V. | Zendy; Ushakov Igor A. | Zendy; Shastin Aleksey V. | Zendy; Balenkova Elizabeth S. | Zendy; Haufe Günter | Zendy; Nenajdenko Valentine G. | Zendy

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A Cascade Approach to Captodative Trifluoromethylated Enamines or Vinylogous Guanidinium Salts: Aromatic Substituents as Switches of Reaction Direction

Author(s) -

Rulev Alexander Yu.,

Muzalevskiy Vasiliy M.,

Kondrashov Evgeniy V.,

Ushakov Igor A.,

Shastin Aleksey V.,

Balenkova Elizabeth S.,

Haufe Günter,

Nenajdenko Valentine G.

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900926

Subject(s) - chemistry , trifluoromethyl , nucleophile , nucleophilic addition , trifluoromethylation , cascade , nucleophilic aromatic substitution , fluorine , enamine , medicinal chemistry , organic chemistry , nucleophilic substitution , alkyl , catalysis , chromatography

β‐Halo‐β‐(trifluoromethyl)styrenes readily react with a variety of nitrogen nucleophiles bearing primary amino groups to afford either the captodative trifluoromethylated enamines or vinylogous guanidinium salts in a selective fashion depending on the electronic natures of the aromatic substituents.

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