Synthesis of Functionalized Spiroaziridine‐oxindoles from 3‐Ylideneoxindoles: An Easy Route to 3‐(Aminoalkyl)oxindoles | Zendy

Ammetto I. | Zendy; Gasperi T. | Zendy; Loreto M. Antonietta | Zendy; Migliorini A. | Zendy; Palmarelli F. | Zendy; Tardella P. Antonio | Zendy

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Synthesis of Functionalized Spiroaziridine‐oxindoles from 3‐Ylideneoxindoles: An Easy Route to 3‐(Aminoalkyl)oxindoles

Author(s) -

Ammetto I.,

Gasperi T.,

Loreto M. Antonietta,

Migliorini A.,

Palmarelli F.,

Tardella P. Antonio

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900891

Subject(s) - chemistry , aziridine , oxindole , regioselectivity , carbamate , sulfonyl , ring (chemistry) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl

Novel potentially bioactive spiroaziridine‐oxindoles have been prepared by treatment of easily accessible 3‐ylideneoxindoles with N ‐{[(4‐nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO 2 Et) in the presence of CaO. These compounds gave new 3‐(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring‐opening reactions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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