Premium
Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R′P(O)OHR″
Author(s) -
Fougère Cécile,
Guénin Erwann,
Hardouin Julie,
Lecouvey Marc
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900852
Subject(s) - phosphinate , chemistry , alkylation , medicinal chemistry , base (topology) , combinatorial chemistry , organic chemistry , catalysis , mathematical analysis , mathematics , fire retardant
A new synthesis of unsymmetrical phosphinic acids R′P(O)OHR″ has been evaluated. The first P–C bond was formed by base‐promoted H‐phosphinate alkylation of a protected H‐phosphinate, which is easier and safer to handle. A one‐pot methodology was developed for the second P–C bond formation reaction that involves the sila‐Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom