Premium
Synthesis of 1‐Substituted Benzimidazoles from o ‐Bromophenyl Isocyanide and Amines
Author(s) -
Lygin Alexander V.,
de Meijere Armin
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900820
Subject(s) - chemistry , isocyanide , primary (astronomy) , medicinal chemistry , catalysis , organic chemistry , physics , astronomy
o ‐Bromophenyl isocyanide ( 1 ‐Br) reacts with various primary amines under Cu I catalysis to afford 1‐substituted benzimidazoles 4 in moderate to good yields (38–70 %, 13 examples). Analogously, 2‐bromo‐3‐isocyanothiophene ( 6 ) furnishes 3‐substituted 3 H ‐thieno[2,3‐ d ]imidazoles 7 (44–49 %, 3 examples). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom