Premium
Synthesis of Novel gluco ‐ and galacto ‐Functionalized Platinum Complexes
Author(s) -
Möker Janina,
Thiem Joachim
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900691
Subject(s) - chemistry , platinum , oxaliplatin , glycoconjugate , carboplatin , cisplatin , malonate , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , catalysis , chemotherapy , cancer , medicine , colorectal cancer , surgery
Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ω‐halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. First tests with different tumour cell lines show biological activity of the gluco ‐functionalized platinum complex.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)