An Unprecedented Approach to the Single‐Step Synthesis of 3,4‐Fused Pyrimidin‐2‐one and Pyrimidin‐2‐thione Derivatives by a [3+2+1] Annulation | Zendy

Sasada Toshiaki | Zendy; Moriuchi Masato | Zendy; Sakai Norio | Zendy; Konakahara Takeo | Zendy

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An Unprecedented Approach to the Single‐Step Synthesis of 3,4‐Fused Pyrimidin‐2‐one and Pyrimidin‐2‐thione Derivatives by a [3+2+1] Annulation

Author(s) -

Sasada Toshiaki,

Moriuchi Masato,

Sakai Norio,

Konakahara Takeo

Publication year - 2009

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200900639

Subject(s) - chemistry , triphosgene , annulation , carbon disulfide , reagent , nitrile , imine , combinatorial chemistry , organic chemistry , catalysis , phosgene

An unprecedented three‐component coupling reaction was developed for the synthesis of 3,4‐fused pyrimidin‐2‐one and pyrimidin‐2‐thione derivatives from an α‐acidic imine compound, a nitrile, and triphosgene or carbon disulfide. This method can be used to easily prepare a variety of pyrimidines from commercially available reagents in a single step. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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