Premium
An Unprecedented Approach to the Single‐Step Synthesis of 3,4‐Fused Pyrimidin‐2‐one and Pyrimidin‐2‐thione Derivatives by a [3+2+1] Annulation
Author(s) -
Sasada Toshiaki,
Moriuchi Masato,
Sakai Norio,
Konakahara Takeo
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900639
Subject(s) - chemistry , triphosgene , annulation , carbon disulfide , reagent , nitrile , imine , combinatorial chemistry , organic chemistry , catalysis , phosgene
An unprecedented three‐component coupling reaction was developed for the synthesis of 3,4‐fused pyrimidin‐2‐one and pyrimidin‐2‐thione derivatives from an α‐acidic imine compound, a nitrile, and triphosgene or carbon disulfide. This method can be used to easily prepare a variety of pyrimidines from commercially available reagents in a single step. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)