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Amination of Alcohols Catalyzed by Copper‐Aluminium Hydrotalcite: A Green Synthesis of Amines
Author(s) -
Likhar Pravin R.,
Arundhathi Racha,
Kantam Mannepalli Lakshmi,
Prathima Parvathaneni Sai
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900628
Subject(s) - chemistry , hydrotalcite , catalysis , amination , imine , copper , organic chemistry , reductive amination , alkylation , aluminium
Copper‐aluminium hydrotalcite (CuAl‐HT)/K 2 CO 3 has been employed in the activation of various benzyl alcohols with benzylamines to afford the corresponding amines in good to high yields. Experimentation showed that the reaction takes place through sequential transformations: the oxidation of alcohols into carbonyl compounds, imine formation between amines and carbonyl compounds, and then reduction ofimines to amines, heterogeneously catalyzed by non‐noble Cu‐Al HT catalyst in a one‐pot and straightforward fashion. The process was further extended to amination of alcohols with anilines, which are often resistant to alkylation reactions when substituted with strong electron‐withdrawing groups. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)