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A Highly Enantioselective Receptor for Carbamoyl Lactic Acid
Author(s) -
Muñiz Francisco M.,
Simón Luis,
Alcázar Victoria,
Raposo César,
Fuentes de Arriba Ángel L.,
Morán Joaquín R.
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900620
Subject(s) - chemistry , enantioselective synthesis , enantiomer , fluorescence , oxyanion , substrate (aquarium) , oxyanion hole , stereochemistry , carboxylic acid , combinatorial chemistry , organic chemistry , molecule , catalysis , hydrogen bond , quantum mechanics , oceanography , geology , physics
A new receptor based on a 9,9‐dimethylxanthene framework was synthesized. Owing to its suitable oxyanion hole structure, this receptor is able to associate carboxylic acids and anions. The introduction of a chiral center provides enantioselective properties to this receptor as a result of its different interactions with both enantiomers of the substrate. The combination of this skeleton with a fluorescent unit such as dansyl allows the detection of small amounts of carboxylic acids by making use of fluorescent techniques.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)