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Ligand‐Free Iron/Copper‐Cocatalyzed Amination of Aryl Iodides
Author(s) -
Wu XiaoFeng,
Darcel Christophe
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900588
Subject(s) - chemistry , amination , aryl , iodide , ammonia , ligand (biochemistry) , aqueous solution , ethanol , copper , combinatorial chemistry , organic chemistry , catalysis , biochemistry , alkyl , receptor
The Fe 2 O 3 /CuI system efficiently catalyzes the direct amination of aryl iodides with aqueous ammonia in ethanol at 90 °C under aerobic conditions. No ligand was used to perform such reaction. A very wide variety of functional groups was tolerated on the aryl iodide partner. This procedure is economically and environmentally attractive as a result of the use of aqueous ammonia and ethanol.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)