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Aromatic Enamide/Ene Metathesis toward Substituted Indoles and Its Application to the Synthesis of Indomethacins
Author(s) -
Kasaya Yayoi,
Hoshi Kosuke,
Terada Yukiyoshi,
Nishida Atsushi,
Shuto Satoshi,
Arisawa Mitsuhiro
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900520
Subject(s) - chemistry , metathesis , ene reaction , steric effects , salt metathesis reaction , ring closing metathesis , organic chemistry , stereochemistry , combinatorial chemistry , polymerization , polymer
A steric and electronic effect on enamide/ene metathesis, a novel preparation of 2‐substituted indoles and 3‐substituted indoles using enamide‐ene metathesis as a key reaction, and its application to the synthesis of indomethacin are described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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