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Versatile Synthesis of Secondary 2‐Amino Thiols and/or Their Disulfides via Thiazolinium Salts
Author(s) -
Mercey Guillaume,
Lohier JeanFrançois,
Gaumont AnnieClaude,
Levillain Jocelyne,
Gulea Mihaela
Publication year - 2009
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200900514
Subject(s) - chemistry , salt (chemistry) , sulfur , thiol , combinatorial chemistry , organic chemistry , amino acid , biochemistry
Commercially available β‐amino alcohols have been transformed into various secondary β‐amino thiols and/or their disulfides by using methyl dithioacetate as a source of sulfur. The transformation involves a thiazolinium salt as a versatile key intermediate, which enables easy modulation of the product structure by varying the substituents on the heterocycle and the N ‐alkylating agent.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)